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Polycystic Ovary Syndome (PCOS): Know the signs, take action!

Illustration showing PCOS signs and the importance of taking action for women’s health
Early recognition of PCOS signs is the first step to taking control of your health and future.
Illustration showing PCOS signs and the importance of taking action for women’s health
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Polycystic Ovary Syndome (PCOS): Know the signs, take action!

What is Polycystic Ovary Syndrome (PCOS)

Polycystic Ovary Syndrome (PCOS) is a hormonal disorder that affects how the ovaries function. In this condition, the ovaries produce higher-than-normal levels of androgens (male hormones), which disrupt the normal balance of reproductive hormones. This imbalance can lead to irregular menstrual cycles, missed periods, or unpredictable ovulation.

On ultrasound, some women with PCOS may have multiple small fluid-filled sacs (follicles) containing immature eggs due to reduced or absent ovulation. Despite its name, not all women with PCOS will have ovarian cysts, and when present, these cysts are usually harmless and not painful.

PCOS is also one of the leading causes of infertility in women, as it interferes with ovulation. Beyond fertility, it may increase the risk of other health problems, including metabolic and cardiovascular conditions. Treatment is typically tailored to the individual, focusing on symptom management, regulating menstrual cycles, and supporting women who wish to conceive.

What Causes PCOS?

The exact cause of Polycystic Ovary Syndrome (PCOS) is still not fully understood, but research shows that both genetic and environmental factors play a role in its development.

Because PCOS often runs in families, genetics has been a major focus of ongoing studies. Recent findings suggest that there may be around 19 genetic variations that increase the likelihood of developing PCOS. These variations may also explain why symptoms and severity can differ widely from one individual to another.

Signs and Symptoms of PCOS:

The presentation of PCOS can vary, but the most common signs and symptoms include: Menstrual irregularities: Infrequent, irregular, or prolonged menstrual cycles. Hyperandrogenism: Elevated levels of male hormones leading to acne, excess facial or body hair (hirsutism), and scalp hair thinning. Polycystic ovaries: Enlarged ovaries with multiple small follicles visible on ultrasound. Weight gain or obesity: Especially central obesity, which may worsen insulin resistance. Skin changes: Darkened patches (acanthosis nigricans), oily skin, or skin tags.

Diagnosis of PCOS

Diagnosis is usually based on the Rotterdam Criteria (2003), which requires two out of three of the following features (after excluding other causes):
  1. Irregular or absent ovulation (oligo- or anovulation).
  2. Clinical or biochemical signs of hyperandrogenism.
  3. Polycystic ovaries seen on ultrasound.
Additional tests may include: Blood tests: To check hormone levels (LH, FSH, testosterone, prolactin, TSH). Glucose and lipid profile: To assess insulin resistance and cardiovascular risk. Pelvic ultrasound: To evaluate ovarian morphology.

Concerns About Fertility

One of the major concerns women with PCOS face is difficulty conceiving due to irregular ovulation or anovulation. However, it is important to highlight that many women with PCOS can achieve pregnancy with appropriate management. Fertility support options include lifestyle modification, medical therapy (such as ovulation induction agents), and assisted reproductive technologies (ART) when required. Early diagnosis and tailored treatment significantly improve outcomes.

Treatment Options for PCOS

Treatments for infertility due to PCOS include lifestyle changes, medicines, or surgery to stimulate regular ovulation. In vitro fertilization (IVF) may be used.

Lifestyle Modifications:

Weight management: Even a 5–10% reduction in body weight can improve menstrual regularity and fertility. Healthy diet: A balanced diet low in refined carbohydrates and rich in whole grains, fruits, and vegetables helps manage insulin resistance. Physical activity: Regular exercise improves insulin sensitivity and overall health.

Medical Treatments:

Hormonal therapy: Combined oral contraceptives to regulate menstrual cycles and reduce androgen excess. Ovulation induction: Medications such as letrozole or clomiphene citrate are used to stimulate ovulation in women planning pregnancy. Insulin sensitizers: Metformin may help with insulin resistance and menstrual regularity. Anti-androgen therapy: Spironolactone (in selected cases) for hirsutism and acne.

Emotional Support Matters

PCOS affects more than just physical health. Support groups, counselling, and open conversations can make a big difference.

For women who do not respond to initial treatments, options include:

Ovarian drilling (surgical procedure). Assisted reproductive technologies (ART): In vitro fertilization (IVF) may be considered in resistant cases.

PCOS Has Long-Term Health Risks

Women with PCOS are at increased risk of:

Type 2 diabetes and gestational diabetes.

Hypertension and cardiovascular disease.

Endometrial hyperplasia and cancer (due to unopposed oestrogen exposure).

Psychological impact, including anxiety, depression, and reduced quality of life.

Final Thoughts

PCOS is a complex but manageable condition. Early recognition, a multidisciplinary approach, and personalized care can significantly improve both short-term and long-term health outcomes. Importantly, women should be reassured that fertility is achievable with appropriate support and treatment.

Source:

  1. World Health Organization (WHO): Polycystic Ovary Syndrome. WHO Health Topics
  2. PubMed: Teede HJ, Misso ML, Costello MF, et al. “International evidence-based guideline for the assessment and management of polycystic ovary syndrome 2018.” Hum Reprod 2018;33(9):1602–1618.
  3. https://www.nih.gov/. https://www.nichd.nih.gov/health/topics/factsheets/pcosl
  4. Polycystic Ovary Syndrome (PCOS)

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